Fontbonne is proud to have partnerships with several colleges and universities:
- Brown University: Through Brown's Pre-College Program, students enroll in an online course facilitated by professors and graduate students at Brown.
- St. Francis College: Qualifying students in grades 11 or 12 can dual enroll in a variety of courses. Students can also enroll in a non-credit Nursing Seminar, where they can visit and take part in workshops in a state-of-the-art nursing lab. See below for registration details.
- St. John's University: Through the College Advantage Program, eligible students in grades 11 or 12 can dual enroll in a variety of courses. See below for registration details.
- St. Joseph's College: Students interested in a child studies career, can dual enroll in classes that are required for majors in the child study field. Students must be in grade 11 or 12 and must meet eligibility requirements. See below for registration details.